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Scientific Publications

Foundational Science

Nicotinic acetylcholine receptor redux: Discovery of accessories opens therapeutic vistas

Matta et al. Science (2021) 373: 6539

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Targeting receptor complexes: a new dimension in drug discovery

Rosenbaum et al. Nature Reviews Drug Discovery (2020) 19: 884

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Getting a Handle on Neuropharmacology by Targeting Receptor-Associated Proteins

Maher et al. Neuron (2017) 96: 989

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Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8

Maher et al. The Journal of Pharmacology and Experimental Therapeutics (2016) 357: 394

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Epilepsy

RAP-219 a Novel, Potent, and Selective Negative Modulator of AMPAR/TARPγ8

Arnold Gammaitoni, Pharm.D. SVP, Medical Affairs, Rapport Therapeutics

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Novel Design of a Focal Epilepsy Proof-of-Concept Study of RAP-219, a Negative Allosteric Modulator of the γ8 Transmembrane AMPA Receptor Associated Protein (TARPγ8)

Jose A. Matta, PhD, Weston Davini, MS, Laurie P. Volak, PhD, Brock T. Shireman, PhD, and David Bredt, MD, PhD

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Early detection rate changes from a brain-responsive neurostimulation system predict efficacy of newly added antiseizure drugs

Quraishi et al, Epilepsia (2019) 61:138–148

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How do we choose the appropriate animal model for antiseizure therapy development?

Barker-Haliski et al, EXPERT OPINION ON DRUG DISCOVERY (2019) 10: 947–951

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Clinical and electrocorticographic response to antiepileptic drugs in patients treated with responsive stimulation

Skarpass, et al, Epilepsy & Behavior (2018) 83: 192–200

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Pain

RTX-1738 Exhibits Analgesic Activity Across a Broad Range of Preclinical Pain Models

Jose A. Matta, PhD, Weston Davini, MS, Laurie P. Volak, PhD, Brock T. Shireman, PhD, and David Bredt, MD, PhD

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Proteins for increased surface expression of the α6β4 nicotinic acetylcholine receptor: Nothing but good news?

Grant and Lester. The Journal of Clinical Investigation (2020) 130: 5685

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Functional α6β4 acetylcholine receptor expression enables pharmacological testing of nicotinic agonists with analgesic properties

Knowland et al. The Journal of Clinical Investigation (2020) 130:6158

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A randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of ABT-594 in patients with diabetic peripheral neuropathic pain

Rowbotham et al. Pain (2009) 146: 245

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Hearing/Vestibular Disorders

Hair cell α9α10 nicotinic acetylcholine receptor functional expression regulated by ligand binding and deafness gene products.

Gu et al. PNAS (2020) 117: 24534

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Enhancement of the Medial Olivocochlear System Prevents Hidden Hearing Loss

Boero et al. The Journal of Neuroscience (2018) 38: 7440

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The mammalian efferent vestibular system plays a crucial role in vestibulo-ocular reflex compensation after unilateral labyrinthectomy

Hübner et al. Journal of Neurophysiology (2017) 117: 1553

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