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Scientific Publications

Foundational Science

Nicotinic acetylcholine receptor redux: Discovery of accessories opens therapeutic vistas

Matta et al. Science (2021) 373: 6539

Targeting receptor complexes: a new dimension in drug discovery

Rosenbaum et al. Nature Reviews Drug Discovery (2020) 19: 884

Getting a Handle on Neuropharmacology by Targeting Receptor-Associated Proteins

Maher et al. Neuron (2017) 96: 989

Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8

Maher et al. The Journal of Pharmacology and Experimental Therapeutics (2016) 357: 394

Epilepsy

Early detection rate changes from a brain-responsive neurostimulation system predict efficacy of newly added antiseizure drugs

Quraishi et al, Epilepsia (2019) 61:138–148

How do we choose the appropriate animal model for antiseizure therapy development?

Barker-Haliski et al, EXPERT OPINION ON DRUG DISCOVERY (2019) 10: 947–951

Clinical and electrocorticographic response to antiepileptic drugs in patients treated with responsive stimulation

Skarpass, et al, Epilepsy & Behavior (2018) 83: 192–200

Pain

Proteins for increased surface expression of the α6β4 nicotinic acetylcholine receptor: Nothing but good news?

Grant and Lester. The Journal of Clinical Investigation (2020) 130: 5685

Functional α6β4 acetylcholine receptor expression enables pharmacological testing of nicotinic agonists with analgesic properties

Knowland et al. The Journal of Clinical Investigation (2020) 130:6158

A randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of ABT-594 in patients with diabetic peripheral neuropathic pain

Rowbotham et al. Pain (2009) 146: 245

Hearing/Vestibular Disorders

Hair cell α9α10 nicotinic acetylcholine receptor functional expression regulated by ligand binding and deafness gene products.

Gu et al. PNAS (2020) 117: 24534

Enhancement of the Medial Olivocochlear System Prevents Hidden Hearing Loss

Boero et al. The Journal of Neuroscience (2018) 38: 7440

The mammalian efferent vestibular system plays a crucial role in vestibulo-ocular reflex compensation after unilateral labyrinthectomy

Hübner et al. Journal of Neurophysiology (2017) 117: 1553